故事承接《鬼灭之刃柱训练篇》。
Dong-hyeon and Yong-joon coincidentally meet at an acting audition. A strange gentleman appears in front of the both of them who are sick of failing at these auditions and suggests something to them. Meanwhile, Ayaka comes to Korea with her best friend Saori to meet her fiancé, Min-joon's parents. She runs into Dong-hyeon and Yong-joon who ask her to star in something and although she's not up for it, she's ushered into doing it by Shiori who loves handsome men. They move locations to a run-down facility and suddenly all exits are blocked and the four of them are trapped. Ayaka looks for an exit but instead finds cameras put up everywhere and gets the feeling that they are being watched. She suspects Yong-joon and Dong-hyeon of being behind this. Suddenly, young men overdosed with gas appear out of no where and try to rape Ayaka and Shiori. Dong-hyeon and Yong-joon fight them to save the women. All this is recorded live and sent to a crowd who is watching from a theater,enjoying it. Yong-joon and Shiori escape into another room but soon they are gassed and they suddenly want each other so bad. Then Shiori loses her mind and kills Yong-joon. Min-joon is watching this amongst the crowd at the theater. What happened between Ayaka and Min-joon...?
1960年代，香港。高楼林立的后面掩饰不住贫民窟的寒酸破败。由于一小孩被老鼠咬伤，不几日鼠疫蔓延开来。刚开始并未引起当局太大重视，随着入院就诊人数逐渐增多，卫生署派人到贫民区发药灭鼠，怕引起市民恐慌，宣布鼠疫并没有大面积流行。但每日增加的住院病人令当局重视起来，组织医务人员研制疫苗，不过为时已晚，连日出现病人死亡，不少有钱人举家逃往海外。普通贫民则相信迷信，求符消灾。一时间，店铺纷纷关张，机场封闭，个别奸商借机大发横财。当局由于决策被动，造成全港人心惶惶。就在大家感到绝望之机，新型疫苗研发成功......
