该剧主要讲述四个家境、性格、目标全然不同的大一女生，因寝室奇缺，而被安排进来有着霉气怨气聚集地之称的梅苑438寝室，于是便产生了这系列或惊奇或喜剧或温馨或纠结的校园故事！最终四人建立起深厚友谊并得到了蜕变和成长。
Season 5 finds Murder, She Wrote's intrepid Jessica Fletcher in fine sleuthing form, and venturing farther afield from Cabot Cove--a good thing, since at the rate the murders have been happening, that town would be nearly cleaned out. Some of the best episodes take place in more exotic locales like New York (dead man on the street, wearing just one shoe), Montana (a publishing convention gone horribly wrong) and West Virginia (two whistle-blowers at a coal company found gruesomely murdered). Angela Lansbury sparkles with determination and bonhomie, hitting her stride and then some. Jessica's own life backstory is even filled out tantalizingly, especially in the episode "The Last Flight of the Dixie Damsel," in which an investigation is launched into a mysterious cargo plane that is linked, she learns to her horror, to her late husband. The series' other delight is watching for cameos by stars of a certain age, and this season doesn't disappoint, with appearances by Roddy McDowall, Shelley Fabares, and Dinah Shore--but also some up-and-comers like Megan Mullally (proof positive that the Will & Grace whine was a put-on) and future satirist Bill Maher.
