少年符生不谙世事，唯独痴迷医学，非常规的行医手段让城中百姓对他又爱又怕。一桩突如其来的“百医之死”案，不仅令他痛失父亲，更使他蒙上弑父凶手的污名。绝境之中，幸得前来寻医的西川郡主文珏与仗义游侠顾天出手搭救，这才死里逃生。为报救命之恩，符生答应随文珏前往西川救治其父。而在整理父亲遗物时，符生意外发现一个秘密，原来这世间竟藏有一件关乎社稷安稳之物——天书宝藏。百医惨死之局，正是因它而起。更令他心惊的是，宝藏所藏之地，正指向西川；而开启一切的钥匙，竟就在自己手中。为查明真相、也为守护百姓安宁，符生与文珏、顾天并肩踏上寻找“天书”的险途。谜案环环相扣，奇诡之事接连不断，三人在这热血与阴谋交织的旅途中步步为营。然而符生并不知道，他这一步步入局，已在西川城中掀起暗涌波澜……
Season 5 finds Murder, She Wrote's intrepid Jessica Fletcher in fine sleuthing form, and venturing farther afield from Cabot Cove--a good thing, since at the rate the murders have been happening, that town would be nearly cleaned out. Some of the best episodes take place in more exotic locales like New York (dead man on the street, wearing just one shoe), Montana (a publishing convention gone horribly wrong) and West Virginia (two whistle-blowers at a coal company found gruesomely murdered). Angela Lansbury sparkles with determination and bonhomie, hitting her stride and then some. Jessica's own life backstory is even filled out tantalizingly, especially in the episode "The Last Flight of the Dixie Damsel," in which an investigation is launched into a mysterious cargo plane that is linked, she learns to her horror, to her late husband. The series' other delight is watching for cameos by stars of a certain age, and this season doesn't disappoint, with appearances by Roddy McDowall, Shelley Fabares, and Dinah Shore--but also some up-and-comers like Megan Mullally (proof positive that the Will & Grace whine was a put-on) and future satirist Bill Maher.
