立藤美学园,仅仅因为一个入侵者——“它们”,而化作了地狱的坩埚!“它们”袭击人,咬人,产生出新的“它们”席卷了整个学园。在化成恶魔的世界的学园内,小室孝和青梅竹马宫本丽、朋友井豪永,暂时去避难。但是,为了保护丽而被“它们”咬的永却变成了“它们”……剩下来的两人,与其他幸存者,同级同学高城沙耶、平野户田、剑道部主将毒岛冴子、校医鞠川静香汇合,下定决心逃出学园!他们有办法活下来吗!?
The ninja turtles are back! But with a TV show. When the Turtles get accepted as humans, and go to high school while being heroes, they are now being pressured Of Doing both things at the same time. With the OG villain of the 1987 TV show, the turtles also have to fight the Shredder.