超级人工智能“智体”即将引爆全球核弹危机,把世界推向毁灭边缘。而伊森·亨特(汤姆·克鲁斯 饰)和他的IMF小队在上次行动中遭遇重创,团队濒临分崩离析。虽然伊森已获得关闭“智体”的钥匙,但要彻底消灭“智体”,完成这一拯救全人类的终极任务,仍需要IMF小队齐心协力突破重重困难。他们不仅要面对全知全能又无影无形的“智体”与其手下盖布瑞尔(埃塞·莫拉雷斯 饰)的百般阻拦,还要解决来自过去的种种恩怨。每个抉择都关乎信念与命运,等待伊森和IMF小队的,究竟是怎样的结局?
Based on the novel by Karel Capek, the prominent Czech writer of the early 20th century who coined the word robot for his play R.U.R., the story revolves around a discovery of Krakatit - a powerful explosive - by Prokop, an experimental scientist who, following an accidental explosion in his lab, slips in and out of delirium. When he realises that, in a delirious period, he has given the formula for making Krakatit to one of his colleagues, he tries to find the man, who does not realize how dangerous a thing Krakatit is. In the process, he nearly gives his discovery away again to foreign interests, a group of anarchists, and even greater forces of darkness...